目录
硕士报考志愿采集    更新日期:2021年3月26日
姓 名 张建法 性 别
出生年月 1965年12月 籍贯
民 族 汉族 政治面貌 中国共产党党员
最后学历 研究生毕业 最后学位
技术职称 教授 导师类别 博士生导师
导师类型 校内 兼职导师
行政职务 Email jfzhang@mail.njust.edu.cn
工作单位 邮政编码
通讯地址
单位电话 025-84318533
个人主页
指导学科
学科专业(主) 081703|生物化工 招生类别 博、硕士 所在学院 环境与生物工程学院
研究方向

(1)代谢工程与合成生物学; (2)代谢相关疾病的新型药物的分子靶点 (3)微生物代谢产物的应用研究

学科专业(辅) 0831|生物医学工程 招生类别 硕士 所在学院 环境与生物工程学院
研究方向
学科专业(辅) 0830|环境科学与工程 招生类别 博、硕士 所在学院 环境与生物工程学院
研究方向
获奖、荣誉称号

新世纪百千万工程国家级人选;

教育部新世纪人才计划;

国务院政府特殊津贴

科研项目

1. 国家自然科学基金重点项目,面上项目,国际交流项目;

2. 科技部国家重点研发项目,973计划项目;

3. 江苏省重点研发项目。

发表论文

代表性论文

[1] Wang L, Cheng R, Sun X, Zhao Y, Ge W, Yang Y, Gao Y, Ding Z, Liu J, & Zhang J* . Preparation and Gut Microbiota Modulatory Property of the Oligosaccharide Riclinoctaose [J]. Journal of agricultural and food chemistry, 2021, doi: 10.1021/acs.jafc.0c07783.

[2] Sun X, & Zhang J* . (2021). Bacterial exopolysaccharides: chemical structures, gene clusters and genetic engineering. International Journal of Biological Macromolecules, 173, 481-490.

[3] Cheng R, Cheng L, Zhao Y, Wang L, & Zhang J* . (2021). Biosynthesis and prebiotic activity of a linear levan from a new paenibacillus isolate. Applied Microbiology and Biotechnology,105(2):769-787.

[4] Ge W, Wang T, Zhao Y, Yang Y, & Zhang J* . (2021). Period1 mediates rhythmic metabolism of toxins by interacting with cyp2e1. Cell Death & Disease, 12(1):76. doi: 10.1038/s41419-020-03343-7.

[5] Sun X, Wang L, Fu R, Yang Y, & Zhang J* . (2020). The chemical properties and hygroscopic activity of the exopolysaccharide lubcan from paenibacillus sp. zx1905. International Journal of Biological Macromolecules, 164:2641-2650.

[6] Yang Y, & Zhang J*. (2020). Bile acids metabolism and circadian rhythms. AJP Gastrointestinal and Liver Physiology, 319(5):G549-G563.

[7] Sun Q, Yang Y, Wang Z, Yang X, & Zhang J*. (2020). Per1 interaction with gpx1 regulates metabolic homeostasis under oxidative stress. Redox Biology, 37, 101694.doi: 10.1016/j.redox.2020.101694.

[8] Ge W, Gao Y, ZhaoY, Yang Y, & Zhang J* . (2020). Decreased t-cell mediated hepatic injury in concanavalin a-treated plrp2-deficient mice. International Immunopharmacology, 85:106604.doi: 10.1016/j.intimp.2020.106604.

[9] Wu Z, Cheng Y, Yang Y, Gao Y, Sun X,Wang L,Sun Q, & Zhang J*, & Xu, X. .(2020). In vitro and in vivo anti- listeria effect of succinoglycan riclin through regulating mapk/il-6 axis and metabolic profiling. International Journal of Biological Macromolecules, 150, 802-813.

[10] Sun X, Gao Y, Ding Z, Zhao Y, Yang Y, Sun Q, Yang X, Ge W, Xu X, Cheng R, & Zhang J* . (2020). Soluble beta-glucan salecan improves vaginal infection of candida albicans in mice. International Journal of Biological Macromolecules, 148, 1053-1060.

[11] Yang Y, Sun X, Zhao Y, Ge W, Ding Z, Liu J, Wang L, Xu X, & Zhang J* .(2020). Anti-tumor activity and immunogenicity of a succinoglycan riclin. Carbohydrate Polymer,255:117370.doi: 10.1016/j.carbpol.2020.117370.

[12] Yang X, Zhao Y, Sun, Q, Yang, Y, & Zhang J* .(2020). Adenosine accumulation causes metabolic disorders in testes and associates with lower testosterone level in obese mice. Molecular Reproduction and Development, 87(2):241-250.

[13] Cheng R, Wang L, Li J, Fu R, Wang S , & Zhang J*. In vitro and in vivo anti‐inflammatory activity of a succinoglycan Riclin from Agrobacterium sp. ZCC3656 [J]. Journal of Applied Microbiology. 2019. 127(6):1716-1726.

[14] Yang Y, Sun Q, Xu X, Yang X, Gao Y, Sun X, Zhao Y, Ding Z, Ge W, Cheng R, & Zhang J*. Oral Administration of Succinoglycan Riclin Improves Diet-Induced Hypercholesterolemia in Mice [J]. Journal of Agricultural and Food Chemistry. 2019;67:13307-13317.

[15] Yang X, Zhao Y, Sun Q, Yang Y, Gao Y, Ge W, Liu J, Xu X, Wen D, Wang S, & Zhang J*, Adenine nucleotide-mediated regulation of hepatic PTP1B activity in mouse models of type 2 diabetes [J]. Diabetologia, 2019, 62(11): 2106-2117.

[16] Cheng R, Cheng L, Wang L, Fu R, Sun X, Li J, Wang S , & Zhang J*. Characterization of an alkali-stable xyloglucanase/mixed-linkage β-glucanase Pgl5A from Paenibacillus sp. S09 [J]. International Journal of Biological Macromolecules. 2019;140:1158-1166.

[17] Gao Y, Lu W, Sun Q, Yang X, Liu J, Ge W, Yang Y, Zhao Y, Xu X , & Zhang J*. Pancreatic lipase-related protein 2 is responsible for the increased hepatic retinyl ester hydrolase activity in vitamin A-deficient mice [J]. The FEBS Journal. 2019;286:4232-4244.

[18] Yang X, Zhao Y, Sun Q, Yang Y, Gao Y, Ge W, Liu J, Xu X , & Zhang J*. An Intermediary Role of Adenine Nucleotides on Free Fatty Acids-Induced Hyperglycemia in Obese Mice [J]. Front Endocrinol. 2019;10:497-497.

[19] Gao Y, Sun Q, Yang X, Lu W, Zhao Y, Ge W, Yang Y, Xu X , & Zhang J*. Orally administered salecan ameliorates methotrexate-induced intestinal mucositis in mice [J]. Cancer Chemotherapy and Pharmacology. 2019;84:105-116.

[20] Xu X, Ding Y, Yang Y, Gao Y, Sun Q, Liu J, Yang X, Wang J , & Zhang J*. β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice [J]. Nutrients. 2018;10:858.doi:10.3390 / nu10070858

[21] Sun Q, Li M, Yang X, Xu X, Wang J , & Zhang J*. Dietary salecan reverts partially the metabolic gene expressions and NMR-based metabolomic profiles from high-fat-diet-induced obese rats [J]. The Journal of Nutritional Biochemistry. 2017;47:53-62

[22] Sun Q, Zhao Y, Yang Y, Yang X, Li M, Xu X, Wen D, Wang J, & Zhang J*. Loss of the clock protein PER2 shortens the erythrocyte life span in mice [J]. Journal of Biological Chemistry, 2017, 292(30): 12679-12690.

[23] Xu L, Cheng R, Li J, Wang Y, Zhu B, Ma S, Zhang W, Dong W, Wang S , & Zhang J*. Identification of substituent groups and related genes involved in salecan biosynthesis in Agrobacterium sp. ZX09 [J]. Appl Microbiol Biot. 2017;101:585-598.

[24] Xu L, & Zhang J*. Bacterial glucans: production, properties, and applications [J]. Appl Microbiol Biot. 2016;100:9023-9036.

[25] Wang T, Wang Z, Yang P, Xia L, Zhou M, Wang S, Du J, & Zhang J*. PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice [J]. Cell death & disease, 2016, 7(4): e2176.doi: 10.1038/cddis.2016.9.

[26] Xia L, Wang Z, Zhang Y, Yang X, Zhan Y, Cheng R, Wang S, & Zhang J*. Reciprocal regulation of insulin and plasma 5′-AMP in glucose homeostasis in mice [J]. Journal of Endocrinology, 2015, 224(3): 225-234.

[27] Xia L, Ma S, Zhang Y, Wang T, Zhou M, Wang Z, & Zhang J*. Daily variation in global and local DNA methylation in mouse livers [J]. Plos One. 2015;10:e0118101-e0118101.

[28] Zhou M, Wang Z, Chen J, Zhan Y, Wang T, Xia L, Wang S, Hua Z, & Zhang J*. Supplementation of the diet with Salecan attenuates the symptoms of colitis induced by dextran sulphate sodium in mice. Br J Nutr. 2014:1-8.

[29] Rui Cheng, Linxiang Xu, Shiming Wang, Yang Wang, & Zhang J*. Recombinant expression and characterization of an acid-, alkali-and salt-tolerant β-1,3-1,4-glucanase from Paenibacillus sp. S09. Biotechnology Letters. 2014, 36: 797-803.

[30] Zhou M, Pu C, Xia L, Yu X, Zhu B, Cheng R, Xu L, & Zhang J*. Salecan diet increases short chain fatty acids and enriches beneficial microbiota in the mouse cecum. Carbohydrate Polymers. 2014, 102:772-779.

[31] Zhan Y, Wang Z, Yang P, Wang T, Xia L, Zhou M, Wang Y, Wang S, Hua Z, & Zhang J*. Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide -induced liver injury in mice through an adenosine receptors-independent mechanism. Cell Death Disease. (2014) 5, e985.doi: 10.1038/cddis.2013.516.

[32] Wang T, Yang P, Zhan Y, Xia L, Hua Z, & Zhang J*. Deletion of circadian gene Per1 alleviates acute ethanol-induced hepatotoxicity in mice. [J]. Toxicology, 2013, 314(2): 193-201.

[33] Cheng R, Chen J, Yu X, Wang Y, Wang S, & Zhang J*. Recombinant production and characterization of full-length and truncated β-1,3-glucanase PglA from Paenibacillus sp. S09. BMC Biotechnology. 2013, 13:105.doi: 10.1186/1472-6750-13-105.

[34] Yang P, Wang Z, Zhan Y, Wang T, Zhou M, Xia L, Yang X, & Zhang J*. Endogenous A1 adenosine receptor protects mice from acute ethanol-induced hepatotoxicity.[J]. Toxicology, 2013: 100-106.

[35] Zhou M, Jia P, Chen J, Xiu A, Zhao Y, Zhan Y, Chen P, & Zhang J*. Laxative effects of Salecan on normal and two models of experimental constipated mice. BMC Gastroenterol. 2013;13:52.doi: 10.1186/1471-230X-13-52.

[36] Yang P, Chen P, Wang T, Zhan Y, Zhou M, Xia L, Cheng R, Guo Y, Zhu L, & Zhang J*. Loss of A(1) adenosine receptor attenuates alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice. Toxicol Sci. 2013;131(1):128‐138

[37] Chen P, Wang Z, Zeng L,Wang S, Dong W, Jia A, Cai C, & Zhang J*. Protective effects of salecan against carbon tetrachloride-induced acute liver injury in mice[J]. Journal of Applied Toxicology, 2012, 32(10): 796-803.

[38] Zhang Y, Wang Z, Zhao Y, Zhao M, Wang S, Hua Z, & Zhang J*. The plasma 5'-AMP acts as a potential upstream regulator of hyperglycemia in type 2 diabetic mice. Am J Physiol Endocrinol Metab, 2012, 302(3):E325-33.

[39] Xiu A, Zhan Y, Zhou M, Zhu B, Wang S, Jia A, Dong W, Cai C, & Zhang J*. Results of a 90-day safety assessment study in mice fed a glucan produced by Agrobacterium sp. ZX09. Food Chem Toxicol. 2011; 49:2377-2384.

[40] Pang W#, Zhang Y#, Wang S, Jia A, Dong W, Cai C, Hua Z, & Zhang J*. The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver. J Lipid Res,2011, 52(5):934-41.

[41] Chen P, Han Z, Yang P, Zhu L, Hua Z,& Zhang J*. Loss of clock gene mPer2 promotes liver fibrosis induced by carbon tetrachloride [J]. Hepatology Research, 2010, 40(11): 1117-1127

[42] Daniels I S, Zhang J, O'brien W G, Tao Z, Miki T, Zhao Z,Blackburn M R, Lee C C. A role of erythrocytes in adenosine monophosphate initiation of hypometabolism in mammals [J]. Journal of Biological Chemistry, 2010, 285(27): 20716-20723.

[43] Chen P, Kakan X,& Zhang J*. Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride [J]. FEBS Letters, 2010, 584(8): 1597-1601.

[44] Chen P, Li C, Pang W, Zhao Y, Dong W, Wang S, & Zhang J*.The protective role of Per2 against carbon tetrachloride-induced hepatotoxicity. Am J Pathol. 2009, 174: 63~70.

[45] Pang W, Li C, Zhao Y, Wang S, Dong W, Jiang P, & Zhang J*. The environmental light influences the circulatory levels of retinoic acid and associates with hepatic lipid metabolism. Endocrinology. 2008 149: 6336-6342.

[46] Zhang J, Kaasik K, Blackburn M R, Lee C C. Constant darkness is a circadian metabolic signal in mammals[J]. Nature, 2006, 439(7074): 340-343.